Even in English-language texts, I’ve seen one of the cities on Sicily’s eastern coast spelled as both Siracusa and Syracuse. The former is the Italian version. The latter is English. I used the Italian here so no one would confuse it with Syracuse, New York.
I don’t remember ever being to Syracuse, New York. If I have been, it was many years ago and only briefly. Nevertheless, I imagine it’s impossible to confuse the two.
The Sicilian Siracusa is a beautiful city lousy with both Greek and Roman ruins, along with some beautiful, still standing old buildings.